CAS No. 79-62-9
Batch:
Purity:
Chemical Structure
Check the
Dihydrolanosterol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (3S,5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol | |
|---|---|---|
| CAS Number | 79-62-9 | |
| Molecular Formula |
C30H52O |
|
| Molecular Weight (MW) | 428.73 | |
| InChIKey | MBZYKEVPFYHDOH-BQNIITSRSA-N |
Biological Activity
Dihydrolanosterol is an endogenous cholesterol biosynthesis intermediate that functions as a selective regulator of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. By inducing conformational changes in HMG-CoA reductase, it accelerates binding to insulin-induced gene (Insig) proteins for ubiquitin-mediated endoplasmic reticulum-associated degradation. This rapid turnover of HMG-CoA reductase suppresses rate-limiting enzymatic activity, thereby downregulating overall cellular cholesterol biosynthesis.[1][2]
How to Prepare Stock Solution?
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Concentration
Volume
Mass
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Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethyl acetate | 5 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.