CAS No. 483-15-8
Batch:
Purity:99.22
Chemical Structure
Check the
Dihydroberberine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 483-15-8 | |
|---|---|---|
| Molecular Formula |
C20H19NO4 |
|
| Molecular Weight (MW) | 337.37 | |
| SMILES | COC1=CC=C2C=C3N(CCC4=C3C=C5OCOC5=C4)CC2=C1OC |
Dihydroberberine is a hydrogenated alkaloid derivative of berberine that inhibits mitochondrial respiratory complex I and dual-modulates NF-kB and MAPK signaling pathways. Inhibition of complex I leads to AMP-activated protein kinase (AMPK) activation and improved insulin sensitivity. Suppression of NF-kB and MAPK signaling attenuates inflammatory cell infiltration and decreases pro-inflammatory mediators including IL-6, IL-1β, and TNF-α. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(100.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.