CAS No. 7327-87-9
Batch:
Purity:99.94
Chemical Structure
Check the
Dihydralazine sulphate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (4-hydrazinylphthalazin-1-yl)hydrazine;sulfuric acid | |
|---|---|---|
| CAS Number | 7327-87-9 | |
| Molecular Formula |
C8H10N6.H2SO4 |
|
| Molecular Weight (MW) | 288.28 | |
| SMILES | C1=CC=C2C(=C1)C(=NN=C2NN)NN.OS(=O)(=O)O | |
| InChIKey | BWHAMWGGORIDBK-UHFFFAOYSA-N |
Biological Activity
Dihydralazine sulphate is a phthalazine-derivative vasodilator and small-molecule DNA methylation inhibitor. It suppresses DNA methyltransferase activity, leading to demethylation of promoter regions and reactivation of epigenetically silenced tumor suppressor genes. Through the inhibition of DNA methylation pathways, dihydralazine alters transcriptional regulation, downregulates oncogenic signaling networks, and suppresses cell proliferation in dependent target cellular models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 8 mg/mL |
| DMSO |
6 mg/mL
(20.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.