CAS No. 1401708-83-5
Batch:
Purity:99.00
Chemical Structure
Check the
Dihexa
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,3S)-N-(6-amino-6-oxohexyl)-2-[[(2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanamide | |
|---|---|---|
| CAS Number | 1401708-83-5 | |
| Molecular Formula |
C27H44N4O5 |
|
| Molecular Weight (MW) | 504.66 | |
| InChIKey | XEUVNVNAVKZSPT-JTJYXVOQSA-N |
Dihexa is an orally active and blood-brain barrier-permeable oligopeptide analog of angiotensin IV that binds to hepatocyte growth factor (HGF) with high affinity, potentiating its activity at the c-Met receptor. Potentiation of HGF/c-Met signaling drives dendritic spinogenesis and synaptogenesis, thereby facilitating neuroprotective signaling and rescuing cognitive deficits in animal models of Alzheimer's disease. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(198.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.