CAS No. 59198-70-8
Batch:
Purity:99.53
Chemical Structure
Check the
Diflucortolone valerate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 59198-70-8 | |
|---|---|---|
| Molecular Formula |
C27H36F2O5 |
|
| Molecular Weight (MW) | 478.57 | |
| SMILES | CCCCC(=O)OCC(=O)C1C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C |
Diflucortolone valerate is a synthetic corticosteroid ester that acts as a potent glucocorticoid receptor agonist. Upon binding to the glucocorticoid receptor, it modulates target gene transcription and suppresses key inflammatory signaling cascades, including the NF-kB pathway. This downstream pathway inhibition reduces the production of pro-inflammatory cytokines and mediators, mediating broad anti-inflammatory, antiproliferative, and immunosuppressive phenotypes in target dermal tissues.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(198.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Diflucortolone valerate Solubility in DMSO
- Diflucortolone valerate Stock Solution
- Diflucortolone valerate Storage
- Diflucortolone valerate Stability
- Diflucortolone valerate Molecular Weight
- Diflucortolone valerate SMILES
- Diflucortolone valerate Chemical Structure (2D and 3D)
- Diflucortolone valerate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.