CAS No. 1642-54-2

Batch: Purity:99.68
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Diethylcarbamazine citrate Chemical Structure
Chemical Structure
Check the Diethylcarbamazine citrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N,N-diethyl-4-methylpiperazine-1-carboxamide;2-hydroxypropane-1,2,3-tricarboxylic acid
CAS Number 1642-54-2
Molecular Formula

C10H21N3O.C6H8O7
Molecular Weight (MW) 391.42
SMILES CCN(CC)C(=O)N1CCN(CC1)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChIKey PGNKBEARDDELNB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Diethylcarbamazine citrate is a highly specific antiparasitic compound that acts as an inhibitor of arachidonic acid metabolism in filarial microfilariae. By interfering with arachidonic acid processing, it suppresses lipid mediator production involved in parasite survival and immune evasion. This disruption impairs microfilarial viability and facilitates host immune-mediated clearance of the parasite, offering potent antifilarial activity without containing toxic metallic elements.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 78 mg/mL
Ethanol 30 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.