CAS No. 67483-13-0
Batch:
Purity:99.45
Chemical Structure
Check the
DIDS sodium salt
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | disodium;5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfonatophenyl)ethenyl]benzenesulfonate | |
|---|---|---|
| CAS Number | 67483-13-0 | |
| Molecular Formula |
C16H10N2O6S4.2Na |
|
| Molecular Weight (MW) | 500.50 | |
| InChIKey | GEPAYBXVXXBSKP-SEPHDYHBSA-L |
DIDS sodium salt is an anion exchange inhibitor and broad-spectrum chloride channel blocker. It directly targets anion exchanger 1 (AE1/Band 3) as well as various calcium-activated and voltage-gated chloride channels, effectively blocking transmembrane anion flux. Downstream disruption of anion transport impairs intracellular pH regulation and cell volume control, altering membrane potential and inducing cellular apoptotic pathways in various cell types. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 10 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.