🛡️ Hazard Overview
- GHS Class: GHS06; GHS07; GHS08; GHS09
- Signal Word: Danger
- Hazard Statements: H301; H302; H371; H372; H373; H411
🧤 PPE Guidelines
- Gloves: Chemical‑resistant gloves suggested
- Eye Protection: Safety goggles suggested
- Respirator: Dust respirator if dust occurs
❄️ Storage
- Storage Temp: -20°C (-4°F) Keep dry
🚑 Emergency First Aid
- For inhalation, skin, eye or ingestion exposure, please refer to full SDS Section 4.
Product identifier
- Product Name: Dicoumarol
- Catalog Number: S4299
- CAS Number: 66-76-2
- IUPAC Name: 3,3'-methylenebis[4-hydroxy-2H-1-benzopyran-2-one
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company: Selleck Chemicals
- TollFree: +1 877 796-6397
- Tel: +1 832 582-8158
- Fax: +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2.1 GHS classification in accordance with 29 CFR 1910 (OSHA HCS):
Acute toxicity (oral): Category 3. H301
Acute toxicity (oral): Category 4. H302
Specific target organ toxicity (single exposure): Category 2. H371
Specific target organ toxicity (repeated exposure): Category 1. H372
Specific target organ toxicity (repeated exposure): Category 2. H373
Chronic aquatic toxicity: Category 2. H411
2.2 GHS Label elements, including precautionary statements
Hazard Pictogram(s):
Signal Word:
Danger
Hazard statement(s):
H301: Toxic if swallowed
H302: Harmful if swallowed
H371: May cause damage to organs
H372: Causes damage to organs through prolonged or repeated exposure
H373: May causes damage to organs through prolonged or repeated exposure
H411: Toxic to aquatic life with long lasting effects
Precautionary statement(s):
Prevention:
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P273: Avoid release to the environment.
Response:
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P301+P317: IF SWALLOWED: Get medical help.
P308+P316: IF exposed or concerned: Get emergency medical help immediately.
P319: Get medical help if you feel unwell.
P321: Specific treatment (see information on this label and safety datasheet)).
P330: Rinse mouth.
P391: Collect spillage.
Storage:
P405: Store locked up.
Disposal:
P501: P501 Dispose of contents/ container to an approved waste disposal plant.
2.3 Other hazards
None.
3.1 Substances
Product name: Dicoumarol
CAS Number: 66-76-2
PubChem CID: 54676038
Molecular formula: C19H12O6
Molecular weight: 336.3 g/mol
IUPAC name: 4-hydroxy-3-[(4-hydroxy-2-oxochromen-3-yl)methyl]chromen-2-one
3.2 Mixtures
Not applicable (pure substance).
4.1 Description of first aid measures
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting unless directed by medical personnel. Seek medical attention.
4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).
4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.
5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.
5.2 Specific hazards arising from the substance or mixture
Combustible. Heating may produce toxic fumes.
5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.
WARNING: Highly toxic — only trained personnel should handle spills.
6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.
6.3 Methods and materials for containment and cleaning up
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Care should be taken ... not to contaminate foodstuffs ... not to leave material within reach of children; to use prepared baits rather than scatter poison; to collect and destroy dead rodents; to bury baits and powder when operation is completed. /coumarin derivatives/
Whereever possible, toxic chemicals, concentrates & bait preparations should be handled in a fume cupboard. When bait mixing has been done in the field, operators should take care to remain sheltered from the wind. /Rodenticides/
Scrupulous personal hygiene must be adhered to when dealing with poisons. All cuts & abrasions on the hands & forearms must be covered with waterproof adhesive dressings before any operations are started. When the work is finished or when a break is taken in the middle /of the day/, protective clothing should be removed & hands washed thoroughly with soap & hot water. Contaminated protective clothing must not be taken into "clean" areas. /Rodenticides/
Smoking, eating & drinking must be strictly prohibited in all rooms in which poisons are present. /Rodenticides/
For more Preventive Measures (Complete) data for DICUMAROL (7 total), please visit the HSDB record page.
7.1 Precautions for safe handling
Dicumarol should be stored in well-closed containers at a temperature below 40 degrees C (104 °F), preferably 15 to 30 °C (59 to 86 °F), and kept away from direct sunlight. The manufacturer recommends storage below 25 °C (77 °F).
7.2 Conditions for safe storage, including any incompatibilities
Dicumarol should be stored in well-closed containers at a temperature below 40 degrees C (104 °F), preferably 15 to 30 °C (59 to 86 °F), and kept away from direct sunlight. The manufacturer recommends storage below 25 °C (77 °F).
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
8.1 Exposure controls
8.1.1 Occupational exposure limits (OEL)
OSHA PEL: Not established.
ACGIH TLV: Not established.
NIOSH REL: Not established.
No occupational exposure limit values are established for this substance.
Use the lowest feasible exposure level (ALARA principle).
8.1.2 Appropriate engineering controls
Use in a well-ventilated area. Chemical fume hood recommended for powder handling.
8.2 Individual protection measures
8.2.1 Eye/face protection
Wear safety glasses with side shields.
8.2.2 Skin protection
Wear protective gloves. Recommended material: Nitrile rubber.
Wear suitable protective clothing (lab coat).
8.2.3 Respiratory protection
Respiratory protection usually not required under normal use with adequate ventilation.
Use N95 respirator for large-scale powder handling.
8.2.4 Thermal hazards
Not applicable.
9.1 Information on basic physical and chemical properties
a) Appearance: White solid with a mild pleasant odor; [HSDB]
b) Odor: Slight, pleasant odor
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 287-293 °C
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: No data available
l) Vapor density: No data available
m) Relative density: No data available
n) Water solubility: Practically insol in water, alc, ether.
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 2.6
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available
9.2 Other information
Topological Polar Surface Area (TPSA): 93.1 Ų
Complexity: 605
10.1 Reactivity
No specific reactivity hazards identified under normal handling conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No hazardous reactions under normal conditions.
10.4 Conditions to avoid
Avoid heat, sparks, open flames, direct sunlight, and moisture.
10.5 Incompatible materials
Strong oxidizing agents, strong acids, strong bases.
10.6 Hazardous decomposition products
Thermal decomposition may produce: Carbon monoxide (CO), Carbon dioxide (CO₂).
See also Section 5 (Fire-fighting measures) for combustion products.
11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
No data available.
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
H371, H372, H373
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.
11.2 Additional information
Carcinogen classification:
No indication of carcinogenicity to humans (not listed by IARC).
Exposure routes:
Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101)
Signs and symptoms of exposure:
Dicoumarol can cause bleeding complications. (L1960)
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.
12.1 Toxicity
LC50 Pimephales promelas (fathead minnow) 5.11 mg/l/96 hr (95% confidence limit 4.18 - 6.24 mg/l), flow-through bioassay with measured concentrations, 24.5 °C, dissolved oxygen 7.2 mg/l, hardness 44.3 mg/l calcium carbonate, alkalinity 44.0 mg/l calcium carbonate, and pH 7.8.
Dicumarol's production and use in anticoagulant therapy may result in its release to the environment through various waste streams; it's former use as a rodenticide resulted in its direct release to the environment. The compound has been isolated from spoiled sweet clover hay. If released to air, an estimated vapor pressure of 6.0X10-17 mm Hg at 25 °C indicates dicumarol will exist solely in the particulate phase in the ambient atmosphere. Particulate-phase dicumarol will be removed from the atmosphere by wet and dry deposition. If released to soil, dicumarol is expected to have moderate mobility based upon an estimated Koc of 320. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.4X10-13 atm-cu m/mole. If released into water, dicumarol is expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 8 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to dicumarol may occur through inhalation an
12.2 Persistence and degradability
No data available.
12.3 Bioaccumulative potential
Log P (n-octanol/water): 2.6
Low potential for bioaccumulation (Log P < 3).
12.4 Mobility in soil
No data available.
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.
12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.
13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.
14.1 UN number
UN 3027
14.2 UN proper shipping name
Coumarin derivative pesticides, solid, toxic, NOS
14.3 Transport hazard class(es)
Consult official transport regulations (DOT/IATA/IMDG) for hazard classification.
14.4 Packing group
Consult official transport regulations (DOT/IATA/IMDG) for packing group assignment.
14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).
14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Not available in public databases.
SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Chronic (long-term) health hazard
Environmental hazard
Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.
California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.
Other regulatory listings:
- California Safe Cosmetics Program (CSCP) Reportable Ingredient: Hazard Traits - Developmental Toxicity Authoritative List - Prop 65 Report - regardless of intended function of ingredient in the product
- FDA Requirements: The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies discontinued drug products. Dicumarol is included on this list.
15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.
Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.