CAS No. 119623-66-4

Batch: Purity:99.95
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Diclofenac Epolamine Chemical Structure
Chemical Structure
Check the Diclofenac Epolamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 119623-66-4
Molecular Formula

C20H24Cl2N2O3
Molecular Weight (MW) 411.32
SMILES OCCN1CCCC1.OC(=O)CC2=C(NC3=C(Cl)C=CC=C3Cl)C=CC=C2

Ordering Information

Biological Activity

Diclofenac Epolamine is a non-steroidal anti-inflammatory agent (NSAID) that acts as an inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). By inhibiting COX enzymatic activity, it suppresses the conversion of arachidonic acid into pro-inflammatory prostaglandins such as PGE2. This reduction in prostaglandin biosynthesis mitigates inflammatory signalling pathways, leading to downstream analgesic, antipyretic, and anti-inflammatory phenotypes in cellular and animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 82 mg/mL
Ethanol 82 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.