CAS No. 15307-86-5
Batch:
Purity:99.94
Chemical Structure
Check the
Diclofenac acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[2-(2,6-dichloroanilino)phenyl]acetic acid | |
|---|---|---|
| CAS Number | 15307-86-5 | |
| Molecular Formula |
C14H11Cl2NO2 |
|
| Molecular Weight (MW) | 296.15 | |
| SMILES | C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl | |
| InChIKey | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
Diclofenac acid is a nonsteroidal anti-inflammatory drug that acts as a dual inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. By inhibiting COX-1 and COX-2 enzymes, it blocks the conversion of arachidonic acid to prostaglandins. This inhibition suppresses downstream inflammatory cascade signaling, leading to pronounced analgesic, anti-inflammatory, and antipyretic biological responses. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.