CAS No. 16980-89-5

Batch: Purity:99.96
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Dibutyryl cAMP (db cAMP/Bucladesine) sodium Chemical Structure
Chemical Structure
Check the Dibutyryl cAMP (db cAMP/Bucladesine) sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium [(4aR,6R,7R,7aR)-6-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
CAS Number 16980-89-5
Molecular Formula

C18H23N5NaO8P
Molecular Weight (MW) 491.37
SMILES CCCC(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]
InChIKey KRBZRVBLIUDQNG-JBVYASIDSA-M

Ordering Information

Biological Activity

Dibutyryl cAMP sodium (Bucladesine sodium) is a cell-permeable cyclic AMP analog that functions as a protein kinase A (PKA) activator and phosphodiesterase (PDE) inhibitor. By mimicking endogenous cAMP, it stimulates cAMP-dependent signaling pathways and regulates intracellular cyclic AMP levels. Activation of the cAMP/PKA pathway drives downstream protein phosphorylation, modulating cellular functions such as cell differentiation, gene expression, and metabolic processes. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (199.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 98 mg/mL
Ethanol 25 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.