CAS No. 364-98-7
Batch:
Purity:99.99
Chemical Structure
Check the
Diazoxide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 364-98-7 | |
|---|---|---|
| Molecular Formula |
C8H7ClN2O2S |
|
| Molecular Weight (MW) | 230.67 | |
| SMILES | CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl |
Diazoxide is a small molecule that acts as an ATP-sensitive potassium (KATP) channel activator in vascular smooth muscle and pancreatic beta-cells. By increasing membrane permeability to potassium ions, it hyperpolarizes the plasma membrane and inhibits voltage-gated calcium entry. This reduction in intracellular calcium influx suppresses insulin secretion from pancreatic beta-cells and promotes relaxation in vascular smooth muscle. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
46 mg/mL
(199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.