CAS No. 78491-02-8
Batch:
Purity:99.92
Chemical Structure
Check the
Diazolidinyl urea
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 78491-02-8 | |
|---|---|---|
| Molecular Formula |
C8H14N4O7 |
|
| Molecular Weight (MW) | 278.22 | |
| SMILES | C(NC(=O)N(CO)C1C(=O)N(C(=O)N1CO)CO)O |
Biological Activity
Diazolidinyl urea is a formaldehyde-releasing preservative with broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as fungi. It acts by releasing formaldehyde, which reacts with microbial proteins and nucleic acids via alkylation. This non-specific chemical modification disrupts cellular membranes, enzymatic activities, and genomic integrity, resulting in the inhibition of microbial cell division and viability.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
55 mg/mL
(197.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.