CAS No. 59156-70-6

Batch: Purity:99
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Di(N-succinimidyl) adipate Chemical Structure
Chemical Structure
Check the Di(N-succinimidyl) adipate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 59156-70-6
Molecular Formula

C14H16N2O8
Molecular Weight (MW) 340.29
SMILES C1CC(=O)N(C1=O)OC(=O)CCCCC(=O)ON2C(=O)CCC2=O

Ordering Information

Biological Activity

Di(N-succinimidyl) adipate is an amine-reactive, alkyl chain-based homobifunctional crosslinker and PROTAC linker. Featuring terminal N-hydroxysuccinimide ester groups, it selectively reacts with primary amines to form stable covalent amide linkages. This compound is utilized in the synthesis of proteolysis targeting chimeras (PROTACs) to connect target protein ligands with E3 ubiquitin ligase recruiters, enabling targeted protein ubiquitination and subsequent proteasomal degradation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.