CAS No. 382-67-2
Batch:
Purity:99.59
Chemical Structure
Check the
Desoximetasone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 382-67-2 | |
|---|---|---|
| Molecular Formula |
C22H29FO4 |
|
| Molecular Weight (MW) | 376.46 | |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1C(=O)CO)C)O)F)C |
Desoximetasone is a synthetic glucocorticoid receptor agonist that selectively binds and activates the glucocorticoid receptor to regulate gene transcription. Ligand binding drives nuclear translocation of the receptor complex, subsequently repressing pro-inflammatory transcription factors such as NF-kB and AP-1. This action downregulates pro-inflammatory cytokine expression and cellular proliferation, leading to potent metabolic, anti-inflammatory, and immunosuppressive functional phenotypes.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.