Home GPCR & G Protein Vasopressin Receptor Desmopressin Acetate For research use only.

Desmopressin Acetate

Synonyms:

Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).

Desmopressin Acetate Chemical Structure

Desmopressin Acetate Chemical Structure

CAS: 62288-83-9

Purity & Quality Control

Batch: Purity: 99.02%
99.02

Desmopressin Acetate Related Products

Signaling Pathway

Vasopressin Receptor Signaling Pathways

Vasopressin Receptor Signaling Pathway

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Biological Activity

Description Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).
In vitro
In vitro Desmopressin (DDAVP) is a selective agonist for the vasopressin V2 receptor (V2R), which is coupled to cAMP-dependent signaling. DDAVP induces cAMP-dependent eNOS activation via Ser1177 phosphorylation[1]. DDAVP (at doses ranging from 100 ng/ml to 1 μg/ml) exerts a modest but significant antiproliferative effect on cultured CT-26 and Colo-205 cells[2].
Cell Research Cell lines HUVECs
Concentrations 1 μM
Incubation Time 25 min
Method

HUVECs are transduced with recombinant adenoviruses AdV2R.EGFP (AdV2R) or AdlacZ. 3 days later cells are incubated for 25 min with 1 μM DDAVP or 10 μM forskolin, both in presence of IBMX. Cell extracts are analyzed for eNOS Ser1177 phosphorylation and eNOS expression.
In Vivo
In vivo In vivo, DDAVP (2 μg/kg) reduces accumulation of ascites and formation of intestinal tumor nodules in mice intraperitoneally inoculated with CT-26 cells. Perioperative administration of DDAVP significantly inhibits tumor progression in animals surgically implanted in the spleen with CT-26 cells, and causes some reduction in liver metastasis. DDAVP is able to inhibit lung colonization by blood-borne breast cancer cells in an experimental murine model. It dramatically reduces lymph node and lung metastasis in a model of mammary tumor manipulation and surgical excision in mice when administered perioperatively, and also exerts antitumor effects in combination with chemotherapy[2]. DDAVP increases the plasma levels of coagulation factor VIII, von Willebrand factor (VWF) and tissue-type plasminogen activator, and also enhances platelet adhesion to the vessel wall[1].
Animal Research Animal Models Syngeneic adult male Balb/c mice inoculated intraperitoneally or intrasplenically with CT-26 colon cancer cells
Dosages 2 μg/kg body weight
Administration i.v.

Chemical Information & Solubility

Molecular Weight 1129.27 Formula

C46H64N14O12S2.C2H4O2
CAS No. 62288-83-9 SDF --
Density 95.0~105.0%
Smiles C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (88.55 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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