CAS No. 19186-35-7
Batch:
Purity:99.97
Chemical Structure
Check the
Deoxypodophyllotoxin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one | |
|---|---|---|
| CAS Number | 19186-35-7 | |
| Molecular Formula |
C22H22O7 |
|
| Molecular Weight (MW) | 398.41 | |
| InChIKey | ZGLXUQQMLLIKAN-SVIJTADQSA-N |
Deoxypodophyllotoxin is a natural lignan derivative of podophyllotoxin isolated from Anthriscus sylvestris that displays potent antimitotic, anti-inflammatory, and antiviral activities. It inhibits tubulin polymerization to destabilize microtubule assembly, leading to G2/M phase cell cycle arrest. This disruption activates ATM/Chk2 signaling, upregulates p53 and Bax expression, and triggers caspase-3 and PARP activation, ultimately driving apoptotic cell death in cancer cells.[1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
80 mg/mL
(200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.