CAS No. 56-94-0

Batch: Purity:99.00
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Demecarium Bromide Chemical Structure
Chemical Structure
Check the Demecarium Bromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide
CAS Number 56-94-0
Molecular Formula

C32H52N4O4.2Br
Molecular Weight (MW) 716.59
SMILES [Br-].[Br-].CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C
InChIKey YHKBUDZECQDYBR-UHFFFAOYSA-L

Ordering Information

Biological Activity

Demecarium bromide is a long-acting anticholinesterase agent that acts as an acetylcholinesterase inhibitor. By suppressing cholinesterase activity, it prevents acetylcholine degradation and enhances cholinergic neurotransmission, downstream inducing persistent miosis. Consequently, this increased cholinergic tone promotes aqueous humor drainage and effectively decreases intraocular pressure in normotensive canine eyes as well as in canine models of inherited glaucoma. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (139.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.