CAS No. 352458-37-8

Batch: Purity:99.90
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Delafloxacin Meglumine Chemical Structure
Chemical Structure
Check the Delafloxacin Meglumine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxoquinoline-3-carboxylic acid;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
CAS Number 352458-37-8
Molecular Formula

C25H29ClF3N5O9
Molecular Weight (MW) 635.97
SMILES CNCC(O)C(O)C(O)C(O)CO.NC1=NC(=C(F)C=C1F)N2C=C(C(O)=O)C(=O)C3=CC(=C(N4CC(O)C4)C(=C23)Cl)F
InChIKey AHJGUEMIZPMAMR-WZTVWXICSA-N

Biological Activity

Delafloxacin meglumine is a broad-spectrum fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV. By inhibiting these essential enzymes, it disrupts bacterial DNA replication and transcription, leading to genomic instability and rapid cell death. Delafloxacin demonstrates potent antibacterial activity against both Gram-positive and Gram-negative bacterial pathogens, including multidrug-resistant and fluoroquinolone-resistant strains. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (157.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nilius AM, et al. Antimicrob Agents Chemother. 2003;47(10):3260-9.

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Note: Technical data last updated: Sep 1, 2026.