CAS No. 138-14-7

Batch: Purity:99.74
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Deferoxamine mesylate Chemical Structure
Chemical Structure
Check the Deferoxamine mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid
CAS Number 138-14-7
Molecular Formula

C26H52N6O11S
Molecular Weight (MW) 656.79
InChIKey IDDIJAWJANBQLJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Deferoxamine mesylate is an iron chelator and ferroptosis inhibitor that stabilizes hypoxia-inducible factor 1-alpha (HIF-1α) expression. By sequestering intracellular ferric iron, it suppresses iron-dependent lipid peroxidation and prevents ferroptotic cell death. Additionally, deferoxamine enhances HIF-1α transactivity under hypoxic and hyperglycemic conditions, promotes autophagy, and reduces beta-amyloid deposition in cellular and animal models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (152.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.