CAS No. 5928-25-6

Batch: Purity:99.06
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Decursin Chemical Structure
Chemical Structure
Check the Decursin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(3S)-2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl] 3-methylbut-2-enoate
CAS Number 5928-25-6
Molecular Formula

C19H20O5
Molecular Weight (MW) 328.36
InChIKey CUKSFECWKQBVED-INIZCTEOSA-N

Ordering Information

Biological Activity

Decursin is a natural pyranocoumarin compound that functions as an inhibitor of NF-kB signaling. It suppresses IkB kinase-mediated IkBa phosphorylation and degradation, thereby preventing NF-kB nuclear translocation and down-regulating downstream gene targets involved in cell proliferation and survival. Consequently, decursin inhibits cancer cell growth, induces apoptosis, and exhibits anti-inflammatory and neuroprotective activities in cellular models.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (200.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 50 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.