Decitabine Mechanism of Action: DNMT Inhibition in Leukemic Blast Cell Research

Decitabine MOA:Targeting DNMT/DNA Methylation Pathway for Combination Targeted Therapy

🎯 check Decitabine product page

Decitabine is a potent, covalent DNA methyltransferase (DNMT) inhibitor. It affects PI3K/AKT/mTOR and Wnt/β-catenin signaling by incorporating into DNA to induce global hypomethylation, effectively reactivating silenced tumor suppressor genes, promoting apoptosis, and inhibiting cancer cell proliferation.

Primary Applications and Mechanism of Action