CAS No. 2543673-19-2
Batch:
Purity:99.39
Chemical Structure
Check the
DCC-3116
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[3-[[2-[2-ethyl-4-(4-methylpiperazin-1-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]propyl]-1,4-oxazepan-5-one | |
|---|---|---|
| CAS Number | 2543673-19-2 | |
| Molecular Formula |
C26H36F3N7O2 |
|
| Molecular Weight (MW) | 535.61 | |
| InChIKey | CNBTYICEJGEABG-UHFFFAOYSA-N |
DCC-3116 is a selective inhibitor of Unc--like kinase 1 and 2 (ULK1/2). By inhibiting ULK1/2 kinase activity, it blocks both basal and sotorasib-induced autophagy pathways. This targeted suppression interrupts cytoprotective stress responses in KRAS G12C-driven cancer cells, leading to enhanced inhibition of cell proliferation and significant anti-tumor activity in preclinical non-small cell lung cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(186.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.