CAS No. 890643-16-0
Batch:
Purity:99.30
Chemical Structure
Check the
DC-05
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-carbazol-9-yl-3-[2-(1H-indol-3-yl)ethylamino]propan-2-ol | |
|---|---|---|
| CAS Number | 890643-16-0 | |
| Molecular Formula |
C25H25N3O |
|
| Molecular Weight (MW) | 383.49 | |
| SMILES | OC(CNCCC1=C[NH]C2=CC=CC=C12)C[N]3C4=CC=CC=C4C5=CC=CC=C35 | |
| InChIKey | LJWMTSMUQJNHOC-UHFFFAOYSA-N |
DC-05 is a small-molecule inhibitor targeting DNA methyltransferase 1 (DNMT1). By inhibiting enzymatic DNMT1 activity, DC-05 disrupts aberrant DNA methylation pathways, promoting the reactivation of epigenetically silenced tumor suppressor genes. This locus-specific demethylation alters chromatin structure and suppresses cellular proliferation through the induction of cell cycle arrest and apoptotic cell death in transformed cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.