CAS No. 1883863-52-2

Batch: Purity:99.72
Check CoA
dBET57 Chemical Structure
Chemical Structure
Check the dBET57 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]acetamide
CAS Number 1883863-52-2
Molecular Formula

C34H31ClN8O5S
Molecular Weight (MW) 699.18
SMILES CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C
InChIKey CZRLOIDJCMKJHE-UXMRNZNESA-N

Biological Activity

dBET57 is a selective proteolysis-targeting chimera (PROTAC) degrader targeting the first bromodomain (BD1) of BRD4 over BD2. By facilitating the recruitment of the cereblon E3 ubiquitin ligase complex to BRD4, dBET57 promotes targeted proteasomal degradation of the BRD4 BD1 protein. This selective target depletion leads to the inhibition of BET family-dependent chromatin interaction pathways, effectively suppressing downstream oncogenic transcriptional networks and cellular proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (143.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Winter GE, et al. Science. 2015;348(6241):1376-81.

Jump to

Note: Technical data last updated: Sep 1, 2026.