CAS No. 929007-72-7
Batch:
Purity:99.98
Chemical Structure
Check the
DB07268
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide | |
|---|---|---|
| CAS Number | 929007-72-7 | |
| Molecular Formula |
C17H15N5O2 |
|
| Molecular Weight (MW) | 321.33 | |
| SMILES | C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O | |
| InChIKey | QHPKKGUGRGRSGA-UHFFFAOYSA-N |
DB07268 is a potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) that targets the mitogen-activated protein kinase (MAPK) signaling pathway. Inhibition of JNK1 prevents the phosphorylation and activation of target transcription factors, including c-Jun and ATF2. This suppression attenuates downstream inflammatory gene expression, regulates cellular stress responses, and impacts programmed cell death and cell proliferation phenotypes.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.