CAS No. 70553-76-3
Batch:
Purity:99.01
Chemical Structure
Check the
Daurisoline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (1R)-1-[[3-[4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]-4-hydroxyphenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol | |
|---|---|---|
| CAS Number | 70553-76-3 | |
| Molecular Formula |
C37H42N2O6 |
|
| Molecular Weight (MW) | 610.74 | |
| SMILES | CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)O)O)OC)OC | |
| InChIKey | BURJAQFYNVMZDV-FIRIVFDPSA-N |
Biological Activity
Daurisoline is a bisbenzylisoquinoline alkaloid isolated from Menispermum dauricum that acts as an autophagy blocker and exhibits antiarrhythmic properties. By inhibiting autophagic flux and disrupting lysosomal function, it leads to the accumulation of autophagosomes within target cells. These cellular changes disrupt key cell survival pathways, resulting in inhibited cell proliferation and suppressed cell viability in biological assays. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(163.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.