CAS No. 20830-81-3
Batch:
Purity:96.57
Chemical Structure
Check the
Daunorubicin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione | |
|---|---|---|
| CAS Number | 20830-81-3 | |
| Molecular Formula |
C27H29NO10 |
|
| Molecular Weight (MW) | 527.52 | |
| InChIKey | STQGQHZAVUOBTE-VGBVRHCVSA-N |
Daunorubicin is an anthracycline antibiotic that functions as a topoisomerase II inhibitor and DNA intercalating agent. Upon binding to nucleic acids, it stabilizes topoisomerase II-cleavable complexes, inhibiting DNA replication and RNA synthesis. This blockade induces double-stranded DNA breaks, activates DNA damage response pathways, and promotes apoptotic cell death in hematopoietic and cancer cell lines. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(22.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.