DAPT is a potent and cell-permeable γ-secretase inhibitor. It affects Notch and amyloid precursor protein (APP) signaling by blocking the proteolytic cleavage of Notch receptors and APP, effectively inhibiting amyloid-beta (Aβ) production and downstream Notch pathway activation.
DAPT Mechanism of Action: γ-secretase Inhibition in Cancer Stem Cells Research
DAPT MOA：Targeting γ-secretase/Notch for Oncology