CAS No. 119356-77-3
Batch:
Purity:99.77
Chemical Structure
Check the
Dapoxetine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine | |
|---|---|---|
| CAS Number | 119356-77-3 | |
| Molecular Formula |
C21H23NO |
|
| Molecular Weight (MW) | 305.41 | |
| InChIKey | USRHYDPUVLEVMC-FQEVSTJZSA-N |
Biological Activity
Dapoxetine is an orally active, short-acting selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter (SERT). By inhibiting SERT, dapoxetine prevents serotonin reuptake into presynaptic neurons, thereby enhancing 5-hydroxytryptamine (5-HT) neurotransmission within central nervous system synapses. This elevation of synaptic serotonin modulates central serotonergic signaling pathways and inhibits the ejaculatory reflex circuit, prolonging latency to ejaculation in preclinical models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.