CAS No. 2034-69-7
Batch:
Purity:99.94
Chemical Structure
Check the
Daphnoretin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2034-69-7 | |
|---|---|---|
| Molecular Formula |
C19H12O7 |
|
| Molecular Weight (MW) | 352.29 | |
| SMILES | COC1=C(O)C=C2OC(=O)C(=CC2=C1)OC3=CC4=C(C=CC(=O)O4)C=C3 |
Daphnoretin is a natural bicoumarin derivative isolated from Wikstroemia indica that acts as a protein kinase C (PKC) activator. By modulating PKC and the downstream AKT signaling pathway, daphnoretin suppresses cell proliferation, invasion, and migration in various cancer cell lines. Furthermore, daphnoretin treatment leads to cell cycle arrest and promotes apoptotic cell death, demonstrating significant anti-tumor activity in preclinical cancer models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(283.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.