CAS No. 960404-48-2

Batch: Purity:99.98
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Dapagliflozin propanediol monohydrate Chemical Structure
Chemical Structure
Check the Dapagliflozin propanediol monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol;(2S)-propane-1,2-diol;hydrate
CAS Number 960404-48-2
Molecular Formula

C21H25ClO6.C3H8O2.H2O
Molecular Weight (MW) 502.98
SMILES CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CC(CO)O.O
InChIKey GOADIQFWSVMMRJ-UPGAGZFNSA-N

Ordering Information

Biological Activity

Dapagliflozin propanediol monohydrate is a potent and selective sodium-glucose cotransporter 2 (SGLT2) inhibitor. By inhibiting renal SGLT2 activity, it blocks glucose reabsorption in the proximal convoluted tubules and promotes urinary glucose excretion. This blockade regulates systemic glucose homeostasis, attenuates glucotoxicity, and reduces blood glucose levels in preclinical models of type 2 diabetes without triggering insulin secretion. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.