Danazol

Catalog No.S9506 Synonyms: WIN-17757; 2,3-Isoxazolethisterone

For research use only.

Danazol (WIN-17757, 2,3-Isoxazolethisterone) is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.

Danazol Chemical Structure

CAS No. 17230-88-5

Purity & Quality Control

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Biological Activity

Description Danazol (WIN-17757, 2,3-Isoxazolethisterone) is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 337.46
Formula

C22H27NO2

CAS No. 17230-88-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05220878 Recruiting Biological: GNR-069|Biological: Nplate Idiopathic Thrombocytopenic Purpura AO GENERIUM September 9 2021 Phase 3
NCT03312400 Recruiting Drug: Danazol Telomere Disease National Heart Lung and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) February 8 2018 Phase 2
NCT03352076 Completed Drug: Vaginal Danazol|Drug: Oral Danatrol Endometriosis Viramal Limited December 28 2017 Phase 2
NCT01001598 Terminated Drug: danazol Fanconi Anemia|Dyskeratosis Congenita Boston Children''s Hospital November 2009 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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