CAS No. 1637781-04-4

Batch: Purity:98.93
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Dalpiciclib Chemical Structure
Chemical Structure
Check the Dalpiciclib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1637781-04-4
Molecular Formula

C25H30N6O2
Molecular Weight (MW) 446.54

Ordering Information

Biological Activity

Dalpiciclib (SHR-6390) is an orally bioavailable, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. By targeting CDK4/6, dalpiciclib inhibits the phosphorylation of retinoblastoma (RB) protein and suppresses the CDK4/6-RB signaling pathway. This blockade exclusively induces G1-phase cell cycle arrest and cellular senescence, resulting in potent antiproliferative and antitumor activity in RB-positive tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.