CAS No. 1009119-65-6

Batch: Purity:99.79
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Daclatasvir Dihydrochloride Chemical Structure
Chemical Structure
Check the Daclatasvir Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate;dihydrochloride
CAS Number 1009119-65-6
Molecular Formula

C40H50N8O6.2HCl
Molecular Weight (MW) 811.8
SMILES CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC.Cl.Cl
InChIKey BVZLLUDATICXCI-JMSCDMLISA-N

Biological Activity

Daclatasvir Dihydrochloride is an orally active hepatitis C virus (HCV) NS5A inhibitor. By targeting the non-structural protein 5A (NS5A), it disrupts both viral RNA replication and virion assembly. Inhibiting NS5A function impairs hyperphosphorylation and alters the localized subcellular structure required for the viral replication complex, thereby potently suppressing HCV viral RNA synthesis and cell-to-cell viral transmission. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (123.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Gao M, et al. Nature. 2010;465(7294):96-100.

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Note: Technical data last updated: Sep 1, 2026.