CAS No. 2065250-25-9

Batch: Purity:99.71
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KUN50259 (DAAO inhibitor-1) Chemical Structure
Chemical Structure
Check the KUN50259 (DAAO inhibitor-1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2065250-25-9
Molecular Formula

C7H5FN2O
Molecular Weight (MW) 152.13
SMILES C1=CC2=C(C=C1F)NNC2=O

Biological Activity

KUN50259 is a potent inhibitor of D-amino acid oxidase (DAAO). DAAO functions as a key enzyme that metabolizes D-serine, an endogenous co-agonist at the glycine site of N-methyl-D-aspartate (NMDA) receptors. By blocking DAAO activity, this compound increases synaptic D-serine levels, thereby promoting NMDA receptor-mediated signaling pathways and modulating excitatory neurotransmission and synaptic plasticity. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (197.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Duplantier AJ, et al. J Med Chem. 2009;52(11):3576-85.

[2] Sacchi S, et al. Curr Pharm Des. 2013;19(14):2499-511.

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Note: Technical data last updated: Sep 1, 2026.