CAS No. 61278-30-6

Batch: Purity:99.83
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D-Saccharic acid 1,4-lactone monohydrate Chemical Structure
Chemical Structure
Check the D-Saccharic acid 1,4-lactone monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 61278-30-6
Molecular Formula

C6H8O7.H2O
Molecular Weight (MW) 210.14
SMILES O.OC1C(O)C(=O)OC1C(O)C(O)=O

Biological Activity

D-Saccharic acid 1,4-lactone monohydrate is a potent β-glucuronidase inhibitor (IC50 = 48.4 μM). By inhibiting β-glucuronidase activity, it prevents the enzymatic cleavage of glucuronosyl-O-bonds in metabolic degradation pathways. This targeted inhibition suppresses the intestinal release of toxic substances and deglucuronidated metabolites, thereby disrupting enterohepatic recycling and protecting colonic tissues against carcinogen-induced cellular damage. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 42 mg/mL (199.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 42 mg/mL
Ethanol 42 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Abid O, et al. Mol Divers. 2021;25(2):995-1009.

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Note: Technical data last updated: Sep 1, 2026.