CAS No. 1224606-06-7

Batch: Purity:
D-Lin-MC3-DMA (MC3) Chemical Structure
Chemical Structure
Check the D-Lin-MC3-DMA (MC3) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl] 4-(dimethylamino)butanoate
CAS Number 1224606-06-7
Molecular Formula

C43H79NO2

 
Molecular Weight (MW) 642.09
SMILES CCCCCC=CCC=CCCCCCCCCC(CCCCCCCCC=CCC=CCCCCC)OC(=O)CCCN(C)C
InChIKey NRLNQCOGCKAESA-KWXKLSQISA-N

Biological Activity

D-Lin-MC3-DMA is an ionizable cationic lipid designed for the systemic delivery of siRNA in vivo. As a core functional component of lipid nanoparticles, it facilitates efficient cellular uptake and endosomal escape into the cytoplasm. This process promotes effective RNA interference (RNAi) pathways, leading to robust target gene silencing in hepatic tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Jayaraman M, et al. Angew Chem Int Ed Engl. 2012;51(34):8529-33.

Jump to

Note: Technical data last updated: Sep 1, 2026.