CAS No. 688342-78-1

Batch: Purity:99.98
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D-I03 Chemical Structure
Chemical Structure
Check the D-I03 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[2-(diethylamino)ethyl]-3-[2-(4-ethylpiperazin-1-yl)-4-methylquinolin-6-yl]thiourea
CAS Number 688342-78-1
Molecular Formula

C23H36N6S
Molecular Weight (MW) 428.64
SMILES CCN1CCN(CC1)C2=NC3=C(C=C(C=C3)NC(=S)NCCN(CC)CC)C(=C2)C
InChIKey UXDGHRWOHOPKIL-UHFFFAOYSA-N

Biological Activity

D-I03 is a selective small-molecule inhibitor of RAD52 that targets the DNA-binding domain to disrupt RAD52-dependent single-stranded DNA annealing and D-loop formation. By blocking RAD52 function, D-I03 impairs homologous recombination-mediated DNA repair pathways, leading to the accumulation of DNA double-strand breaks and inhibition of cellular proliferation. Consequently, treatment with D-I03 selectively induces synthetic lethality in BRCA-deficient cancer cells while sparing normal cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (200.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.