CAS No. 79055-68-8

Batch: Purity:99.24
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D-AP5 Chemical Structure
Chemical Structure
Check the D-AP5 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(4R)-4-amino-4-carboxybutyl]-hydroxyphosphinate
CAS Number 79055-68-8
Molecular Formula

C5H12NO5P
Molecular Weight (MW) 197.13
InChIKey VOROEQBFPPIACJ-SCSAIBSYSA-M

Biological Activity

D-AP5 (D-2-amino-5-phosphonovaleric acid) is a selective and competitive N-methyl-D-aspartate (NMDA) receptor antagonist that targets the glutamate binding site of NMDA receptors. By selectively blocking NMDA receptor-mediated ion channel activation, D-AP5 disrupts glutamatergic excitatory synaptic transmission. Consequently, inhibition of this signaling pathway blocks hippocampal synaptic plasticity and long-term potentiation (LTP), impairing spatial learning and memory formation in animal models. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 39 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lodge D, et al. Br J Pharmacol. 1988;95(3):957-65.

[2] Davis S, et al. J Neurosci. 1992;12(1):21-34.

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Note: Technical data last updated: Sep 1, 2026.