CAS No. 4345-03-3
Batch:
Purity:99.06
Chemical Structure
Check the
D-α-Tocopherol Succinate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 4345-03-3 | |
|---|---|---|
| Molecular Formula |
C33H54O5 |
|
| Molecular Weight (MW) | 530.78 |
D-α-Tocopherol succinate (Vitamin E succinate) is an antioxidant derivative of vitamin E that acts as a ROS scavenger. It significantly reduces cisplatin-induced accumulation of reactive oxygen species (ROS) and attenuates downstream cellular necrosis and late apoptosis. By blocking oxidative stress-mediated apoptotic signaling pathways, D-α-tocopherol succinate protects HEI-OC1 cells against cisplatin-induced cytotoxicity, promoting overall cell survival under stress. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.