CAS No. 916603-07-1
Batch:
Purity:99.91
Chemical Structure
Check the
CZC-8004
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-N-[4-(aminomethyl)phenyl]-5-fluoro-4-N-phenylpyrimidine-2,4-diamine | |
|---|---|---|
| CAS Number | 916603-07-1 | |
| Molecular Formula |
C17H16FN5 |
|
| Molecular Weight (MW) | 309.34 | |
| SMILES | C1=CC=C(C=C1)NC2=NC(=NC=C2F)NC3=CC=C(C=C3)CN | |
| InChIKey | UKOHFWNBTUJMMN-UHFFFAOYSA-N |
CZC-8004 is a broad-spectrum pan-kinase inhibitor that targets a wide range of protein kinases, including ABL kinase. By competing with ATP for binding to the catalytic domain, it disrupts kinase-mediated phosphorylation cascades across diverse cellular signaling pathways. This potent interaction inhibits downstream oncogenic signaling networks and cellular proliferation, making it a valuable tool in chemical proteomics and kinase profiling studies. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(200.42 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.