CAS No. 1191911-27-9

Batch: Purity:99.42
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CZC-54252 Chemical Structure
Chemical Structure
Check the CZC-54252 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
CAS Number 1191911-27-9
Molecular Formula

C22H25ClN6O4S
Molecular Weight (MW) 504.99
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl
InChIKey CLGWUCNXOBLWFM-UHFFFAOYSA-N

Biological Activity

CZC-54252 is a potent and selective small-molecule inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting both human wild-type LRRK2 and the pathogenic G2019S mutant variant. Pharmacological inhibition of LRRK2 kinase activity suppresses downstream cellular autophosphorylation and reduces phosphorylation of key Rab family GTPases, thereby regulating intracellular vesicular trafficking and neuronal autophagy signaling pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (198.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Dzamko N, et al. Biochem J. 2010;430(3):405-13.

[2] Graphene Science Handbook. 2016:337-352.

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Note: Technical data last updated: Sep 1, 2026.