CAS No. 1191911-26-8

Batch: Purity:99.40
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CZC-25146 Chemical Structure
Chemical Structure
Check the CZC-25146 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
CAS Number 1191911-26-8
Molecular Formula

C22H25FN6O4S

 
Molecular Weight (MW) 488.54
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F
InChIKey XXHHOTZUJIXPJX-UHFFFAOYSA-N

Biological Activity

CZC-25146 is a potent and selective LRRK2 inhibitor that targets wild-type LRRK2 (IC50 4.76 nM) and G2019S mutant LRRK2 (IC50 6.87 nM). It suppresses LRRK2 kinase activity, leading to reduced autophosphorylation and inhibition of downstream signaling pathways. In cellular models, CZC-25146 attenuates LRRK2-mediated neurotoxicity and dampens microglial inflammatory responses, demonstrating protective effects in Parkinson's disease research models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (200.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] ACS Med. Chem. Lett. 2011;2(2):90-90.

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Note: Technical data last updated: Sep 1, 2026.