CAS No. 1429639-50-8
Batch:
Purity:99.32
Chemical Structure
Check the
CZ415
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-[7,7-dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-5H-thieno[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea | |
|---|---|---|
| CAS Number | 1429639-50-8 | |
| Molecular Formula |
C22H29N5O4S |
|
| Molecular Weight (MW) | 459.56 | |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CS(=O)(=O)C3(C)C)C(=N2)N4CCOCC4C | |
| InChIKey | IZLPVLBNRGPOHA-AWEZNQCLSA-N |
CZ415 is a potent, cell-permeable, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR). By targeting mTOR, it disrupts both mTORC1 and mTORC2 complex activity within the PI3K/AKT/mTOR signaling pathway. Downstream, this inhibition suppresses anabolic processes such as protein synthesis and cellular growth, while suppressing cell proliferation. Consequently, CZ415 serves as a valuable tool for investigating mTOR-dependent oncogenic signaling. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(198.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.