CAS No. 969-33-5
| CAS Number | 969-33-5 | |
|---|---|---|
| Molecular Formula |
C21H21N.HCl |
|
| Molecular Weight (MW) | 323.86 | |
| SMILES | CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl |
Cyproheptadine HCl is a first-generation histamine receptor antagonist that selectively blocks histamine H1 receptors and serotonin 5-HT receptors. By competing with endogenous histamine and serotonin for receptor binding sites, it inhibits downstream signaling pathways involved in allergic responses, smooth muscle contraction, and vasodilation. Cyproheptadine also exhibits anticholinergic properties, suppressing muscarinic receptor-mediated signaling to modulate cellular phenotypes and neurochemical activity. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 65 mg/mL |
| Water | Insoluble |
| DMSO |
65 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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