CAS No. 1449747-00-5
Batch:
Purity:99.91
Chemical Structure
Check the
CYM-5520
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]-6-oxopyridine-3-carbonitrile | |
|---|---|---|
| CAS Number | 1449747-00-5 | |
| Molecular Formula |
C21H19N3O2 |
|
| Molecular Weight (MW) | 345.39 | |
| SMILES | CC1=CC(=C(C)[N]1CC2=CC=CC=C2)C(=O)CN3C=C(C=CC3=O)C#N | |
| InChIKey | FMYGNANMYYHBSU-UHFFFAOYSA-N |
CYM-5520 is a highly selective allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2) that exhibits no cross-reactivity with other S1P receptor subtypes. Selective activation of S1PR2 by CYM-5520 stimulates downstream G protein-coupled signaling, specifically engaging G12/13 and Rho/ROCK pathways to modulate cellular functions such as cell migration, vascular permeability, and cytoskeletal organization. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.