CAS No. 39711-79-0
Batch:
Purity:99.63
Chemical Structure
Check the
Cyclohexanecarboxamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 39711-79-0 | |
|---|---|---|
| Molecular Formula |
C13H25NO |
|
| Molecular Weight (MW) | 211.34 | |
| SMILES | CCNC(=O)C1CC(CCC1C(C)C)C |
Cyclohexanecarboxamide is a cooling agent that acts as an agonist at TRPM8 receptors with an EC50 of 3.7 μM. Activation of the TRPM8 ion channel induces intracellular calcium influx and depolarizes primary sensory neurons, modulating cold somatosensory signaling pathways. This activation downstream leads to cold sensation responses and somatosensory perception modulation without inducing an actual physical temperature reduction in cells or tissues. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(198.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 42 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.