CAS No. 82-92-8

Batch: Purity:99.43
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Cyclizine Chemical Structure
Chemical Structure
Check the Cyclizine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 82-92-8
Molecular Formula

C18H22N2
Molecular Weight (MW) 266.38
SMILES CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

Ordering Information

Biological Activity

Cyclizine is a first-generation piperazine derivative and antagonist of the histamine H1 receptor. By selectively targeting and inhibiting histamine H1 receptor activation, it suppresses downstream histamine-mediated signaling pathways in the central nervous system. This receptor blockade disrupts histaminergic and cholinergic neurotransmission within the vestibular apparatus and chemoreceptor trigger zone, leading to the alleviation of nausea, motion sickness, and dizziness.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 53 mg/mL (198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 53 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.