CAS No. 17086-76-9

Batch: Purity:99.88
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Cyasterone Chemical Structure
Chemical Structure
Check the Cyasterone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,4S,5R)-4-[(2R,3R)-2,3-dihydroxy-3-[(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]-3,5-dimethyloxolan-2-one
CAS Number 17086-76-9
Molecular Formula

C29H44O8
Molecular Weight (MW) 520.65
SMILES CC1OC(=O)C(C)C1CC(O)C(C)(O)C2CCC3(O)C4=CC(=O)C5CC(O)C(O)CC5(C)C4CCC23C
InChIKey NEFYSBQJYCICOG-YSEUJXISSA-N

Biological Activity

Cyasterone is a natural phytoecdysteroid isolated from Cyathula capitata that acts as an EGFR inhibitor. By targeting the epidermal growth factor receptor (EGFR), it modulates downstream cell survival and proliferation signaling pathways, thereby suppressing cancer cell viability and promoting apoptosis. Cyasterone serves as a promising lead compound in anti-cancer research and the development of targeted therapies against EGFR-driven malignancies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Seshacharyulu P, et al. Expert Opin Ther Targets. 2012;16(1):15-31.

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Note: Technical data last updated: Sep 1, 2026.